Preparation, Characterization and Biological Activity of Some Transition Metal (II) Complexes Containing Cephalexin and Cefotaxime Sodium
DOI:
https://doi.org/10.26750/paperKeywords:
Synthesis, Characterization, Antimicrobial, Cephalexin, Cefotaxime, Metal complexesAbstract
A series of mixed ligand complexes of cephalexin and cefotaxime sodium were prepared. All complexes were characterized by molar conductivity, IR and UV-Visible spectroscopy. All the complexes have Oh geometry with general formula {M(L1)(L2)(H2O)2}, where M= Co(II), Cu(II), Ni(II), V(II), L1= cephalexin, L2= cefotaxime sodium. Antibacterial activity of all the synthesized complexes and ligands were tested against some bacteria. The antibacterial activities of all compounds in case of Pseudomonas aeruginosa at DMSO (10 mg/ml) concentration exhibit not active. The Staphylococcus aureus, Escherichia coli, Salmonella some metal complexes exhibit more activity than ligand.
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R. A. Tirkeso, T. W. Tsega and G. G. Amdemichael, "Synthesis, Characterization, and Antibacterial Activities of 1H-Imidazo [5, 6-f] [1,10] Phenanthroline-2(3H)-Thione and Its Ni(II) and Cu(II) Complexes," Journal of Chemistry, vol. 2019, 2019.
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S.-Y. Zhao, D.-K. Lee, C.-W. Kim, H.-G. Cha, Y.-H. Kim and Y.-S. Kang, "Synthesis of Magnetic Nanoparticles of Fe3O4 and CoFe2O4 and Their Surface Modification by Surfactant Adsorption," Bulletin of the Korean Chemical Society, vol. 27, no. 2, pp. 237-242, 2006.
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Published
2020-08-13
How to Cite
Faraj, R. H., & Salih, S. I. (2020). Preparation, Characterization and Biological Activity of Some Transition Metal (II) Complexes Containing Cephalexin and Cefotaxime Sodium. Journal of University of Raparin, 7(3), 1–17. https://doi.org/10.26750/paper
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Humanities & Social Sciences
