Preparation, Characterization and Biological Activity of Some Transition Metal (II) Complexes Containing Cephalexin and Cefotaxime Sodium
1 Department of Chemistry, Faculty of Science and Health, Koya University, Koya, Kurdistan Region, Iraq.
2 Department of Medical Microbiology, College of Health Sciences, Hawler Medical University, Erbil, Kurdistan Region, Iraq.
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Abstract
A series of mixed ligand complexes of cephalexin and cefotaxime sodium were prepared. All complexes were characterized by molar conductivity, IR and UV-Visible spectroscopy. All the complexes have Oh geometry with general formula {M(L1)(L2)(H2O)2}, where M= Co(II), Cu(II), Ni(II), V(II), L1= cephalexin, L2= cefotaxime sodium. Antibacterial activity of all the synthesized complexes and ligands were tested against some bacteria. The antibacterial activities of all compounds in case of Pseudomonas aeruginosa at DMSO (10 mg/ml) concentration exhibit not active. The Staphylococcus aureus, Escherichia coli, Salmonella some metal complexes exhibit more activity than ligand.
Full Text
Preparation, Characterization and Biological Activity of Some Transition Metal (II) Complexes Containing Cephalexin and Cefotaxime Sodium
Rezhna Hassan Faraj, Shean Ismael Salih
A series of mixed ligand complexes of cephalexin and cefotaxime sodium were prepared. All complexes were characterized by molar conductivity, IR and UV-Visible spectroscopy. All the complexes have Oh geometry with general formula {M(L1)(L2)(H2O)2}, where M= Co(II), Cu(II), Ni(II), V(II), L1= cephalexin, L2= cefotaxime sodium. Antibacterial activity of all the synthesized complexes and ligands were tested against some bacteria. The antibacterial activities of all compounds in case of Pseudomonas aeruginosa at DMSO (10 mg/ml) concentration exhibit not active. The Staphylococcus aureus, Escherichia coli, Salmonella some metal complexes exhibit more activity than ligand.
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